GRADS Alpha 1 Antitrypsin Deficiency

Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Alpha-1 Antitrypsin Deficiency Study

Purpose: Alpha-1 Antitrypsin Deficiency is a genetic condition that predisposes to early onset pulmonary emphysema and airways obstruction, often indistinguishable from usual smoker's chronic obstructive pulmonary disease. The purpose of this study is to study the air way and lung microorganisms in people with Alpha-1 Antitrypsin Deficiency or individuals in the carrier status and the inflammatory response.

For more information visit the GRADS website.

Eligibility: People between the ages of 40 - 80 years with defined Alpha-1 Antitrypsin genotype PiZZ or PiMZ may be eligible.

Sponsor: The National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)

Principal Investigator: Joe G. Garcia, MD

Co-Investigators: Cristine Berry, MD., Kenneth Knox, MD

Contact information: ncasanova@email.arizona.edu

(520) 626-4110 and (520) 626-8221

Study Status: 
Currently Enrolling